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Edward Vargas

8 Essential Strategies for Mastering 340B Drug Pricing Program Compliance & Program Management

Updated: Sep 20

Pharmacist in a pharmacy filling out a form.

A Comprehensive Guide for 340B Drug Pricing Program Managers

The 340B Drug Discount Program is crucial in many healthcare organizations, but managing it effectively to ensure compliance with 340B program requirements can be challenging. This guide covers recent updates, compliance requirements, and strategies for optimizing your 340B operations. Whether you're new to 340B or have years of experience, you'll find valuable insights to help you navigate this complex program that requires drug manufacturers to provide outpatient drugs to covered entities at significantly reduced prices.


Step 1: Understanding the 340B Program: Recent Updates and Importance

The 340B program, established in 1992 as part of Section 340B of the Public Health Service Act, Public Health Service Act, continues to evolve, impacting compliance with 340B program requirements. Recent developments have significantly impacted covered entities, and it's crucial for program managers to stay informed.


Contract Pharmacy Challenges

One of the program's most pressing issues today is the ongoing challenge with contract pharmacy arrangements. Several drug manufacturers have imposed their own policies to restrict 340B pricing for covered entities with contract pharmacy relationships. This has created a complex landscape that requires careful navigation and strategic planning.


Managing relationships with large retail pharmacy chains like CVS and Walgreens has become increasingly complex. These contracts enable covered entities to provide outpatient drugs to more eligible patients but also involve intricate financial agreements governing the division of funds received from third-party insurers.


Legislative Proposals Regarding Discounted Drugs

We're seeing various legislative proposals at both federal and state levels calling for increased transparency in the 340B program. These proposals aim to address the role of contract pharmacies and scrutinize the types of patients and services provided under the program.


Democrats and Republicans in Congress have gathered to form The Senate 340B Bipartisan Working Group to examine the 340B statute and to reform aspects of the 340B program. At the state level, many legislatures have implemented or are considering bills to prevent discrimination against 340B covered entities by drug companies and pharmacy benefit managers (PBMs).


Impact of the Inflation Reduction Act on Covered Entities

The Inflation Reduction Act has introduced changes that could affect 340B ceiling prices, particularly for high-volume prescription drugs like insulin. While it may slightly reduce 340B prices, it could also diminish the savings covered entities realize due to lower Medicare reimbursement rates, impacting covered entities nationwide.


Program Importance

The 340B program allows covered entities to stretch their limited federal resources, expand comprehensive services, and reach more eligible patients with financial constraints. By offering discounted pricing on outpatient drugs, the program enables healthcare organizations to reinvest savings into critical patient services, particularly in public health settings.


Step 2: 340B Compliance Requirements and Regulatory Changes

Staying compliant with 340B regulations is crucial for program integrity. Key compliance requirements include:

  • Accurate registration on the Office of Pharmacy Affairs Information System (OPAIS)

  • Recertifying eligibility annually

  • Prevent diversion to ineligible patients

  • Preventing duplicate discounts

  • Prepare for program audits


Covered entities must adhere to these requirements to maintain program integrity. Recent regulatory changes have focused on contract pharmacy arrangements and increased transparency. It's essential to stay updated on these changes and their potential impact on program compliance.


Common Compliance Pitfalls

In our line of work with 340B programs, we frequently address compliance issues. These include inaccurate record-keeping, errors in patient eligibility determination, insufficient oversight of contract pharmacies, and failure to prevent duplicate discounts. To avoid these pitfalls, it is essential to implement robust internal controls and provide regular staff training.


Maintaining Auditable Records

Auditable records are the backbone of 340B compliance. To ensure record auditability, consider implementing standardized documentation processes and centralizing record-keeping systems. Regular internal audits and comprehensive staff training on documentation procedures are crucial in maintaining compliant records.


Read our blog post on Maintaining Auditable Records to remain prepared for HRSA 340B Audits.


Step 3: 340B Drug Pricing and Contract Management

The 340B price is calculated using a statutory formula based on the Average Manufacturer Price (AMP) and Unit Rebate Amount (URA). This calculation results in 340B ceiling prices; the maximum prices drug manufacturers can charge covered entities. Several factors can influence pricing, including legislative changes like the Inflation Reduction Act, government negotiations on Medicare drug prices, and market dynamics affecting AMP.


Effective contract management is crucial for 340B programs, especially with contract pharmacies. Key aspects include:

  • Clear agreements outlining roles and responsibilities

  • Regular communication with contract pharmacies

  • Robust oversight to ensure compliance


Managing relationships with large retail pharmacy chains requires particular attention due to the complex financial arrangements involved.


For a deeper dive into the aspects of 340B drug pricing, check out our blog 340B Drug Pricing Program Requirements Explained!


Step 4: 340B Audits and Oversight

Program managers should be prepared for various types of audits:

  • HRSA audits (approximately 200 conducted annually)

  • Manufacturer audits

  • Internal audits for self-assessment and compliance with 340B program requirements.


As part of program integrity efforts, HRSA and drug manufacturers can audit covered entities to ensure compliance with program requirements.


Preparing for a HRSA 340B Audit

To prepare for audits, ensure you have these key documents readily available:

  • Eligibility documentation

  • Patient utilization records

  • Drug procurement and inventory records

  • Policies and procedures for preventing duplicate discounts and diversion

  • Contract pharmacy agreements

  • Financial records related to 340B transactions


Consider engaging an independent auditor for a mock audit to identify potential issues before an actual HRSA audit. This proactive approach can help you address compliance gaps before they become problems during an official audit.


Step 5: Strategies for Improved 340B Inventory Management

Effective inventory management is crucial for 340B program success. Key strategies include implementing advanced inventory management systems and developing clear standard operating procedures (SOPs). Regularly reconciling inventory records and monitoring utilization patterns can also help prevent discrepancies and ensure smooth operations.


Best Practices for Managing Inventory Levels

To optimize inventory management:

  • Use technology solutions to track inventory in real-time

  • Implement cycle counting procedures

  • Regularly review and adjust par levels

  • Ensure staff is well-trained in inventory management procedures


Pay particular attention to ensuring all prescriptions filled by eligible prescribers are correctly marked as 340B drugs in your system. This prevents eligible 340B drugs from defaulting to wholesale acquisition costs (WAC) due to mislabeling or missing identifiers, which is crucial for program integrity.


Step 6: Data Integrity and Effective Data Management

Data integrity is crucial for 340B compliance and program success. To ensure accurate reporting:

  • Implement robust data management systems

  • Regularly audit and validate data

  • Train staff on proper data entry and management procedures


Effective data management allows for better decision-making and helps demonstrate program value. You should consider using analytics tools to gain insights from your 340B data, which can help identify areas for improvement and cost savings.


Monitoring Key Metrics

Regularly monitor and report on key metrics, including:

  • Drug spending and monthly trends

  • The volume of prescriptions filled

  • Financial metrics associated with the number of patients served

  • Impact of drug substitutions and shortages on total 340B spend/savings


These metrics provide valuable insights into your program's performance and can help identify areas for optimization.


Step 7: Staff Training and Education on Participating in the 340B Program

Well-trained staff are essential for maintaining 340B compliance. Key areas to focus on in training programs include:

  • 340B program basics and compliance requirements

  • Patient eligibility criteria

  • Inventory management procedures

  • Documentation and record-keeping best practices


HRSA and Apexus Training Resources

The Health Resources and Services Administration (HRSA) offers valuable 340B program education resources. Additionally, Apexus, the HRSA-designated Prime Vendor Program vendor, provides comprehensive training and certification programs. These include:

  • The Apexus Advanced 340B Operations Certificate Program

  • Online learning modules covering various aspects of 340B management

  • Webinars and in-person training events


We strongly recommend that 340B program managers and staff utilize these official training resources. They provide a solid foundation in 340B program requirements and best practices.




Industry Organizations and Resources

Several organizations provide valuable resources and advocacy for 340B program participants:

  • 340B Health: Offers advocacy, education, and resources for covered entities

  • 340B Report: Provides news and updates on the 340B program

  • National Association of Community Health Centers (NACHC): Hosts annual events with networking opportunities





Step 8: Technology and Automation Tools

Leveraging technology can significantly improve 340B program management. Key technologies used in 340B programs include:

  • Inventory management systems

  • Split-billing software

  • Contract pharmacy management tools

  • Data analytics platforms


Automation can help reduce errors, improve efficiency, and enhance compliance. Consider integration capabilities, user-friendliness, and vendor support when selecting technology solutions.


Navigating 340B Success

Managing a 340B Drug Discount Program is complex, but optimizing your program while maintaining compliance is possible with the right strategies and tools. By focusing on compliance, inventory management, audits, data integrity, and staff training, you can ensure your 340B program operates effectively and delivers maximum benefit to your organization and the patients you serve.


Staying informed about regulatory changes and industry best practices is crucial for long-term success in the 340B program. We encourage you to continue your 340B education and seek expert guidance when needed.


For a more in-depth exploration of 340B program management, check out our book, "340B Mastery: Transforming Risk into Reward in Pharmacy Program Management." This comprehensive guide offers detailed strategies and insights to help you navigate the complexities of the 340B program.



If you're looking for personalized guidance on optimizing your 340B program, we're here to help. Schedule a consultation with our team of 340B experts to discuss your specific challenges and goals.



By staying informed, leveraging best practices, and seeking expert support when needed, you can ensure your 340B program maintains compliance and maximizes its potential to serve your community.

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